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Crigler-Najjar syndrome

Crigler-Najjar syndrome is a very rare genetic disorder caused by the deficiency of a specific enzyme responsible for breaking down bilirubin. This causes toxic levels of bilirubin buildup in the body. There are two types of Crigler-Najjar syndrome: Type 1 and Type 2. Individuals with Crigler-Najjar syndrome exhibit jaundice (yellowing of the skin and whites of the eyes). Severe cases can lead to brain and nerve tissue damage.

Treatment is aimed at reducing the amount of bilirubin that has accumulated in the body.

The latest on our research

We are jumpstarting our Crigler-Najjar syndrome program to accelerate research for the condition. We welcome all patients and caregivers interested in participating and spreading the word to the Crigler-Najjar syndrome community.

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Crigler-Najjar syndrome type 1



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